Objectives: Aqishan pluton is located in Shanshan county, Turpan region, Xinjiang province. In geotectonic position, It is located near the boundary between the Kazakh—Zhunge plate and the Tarim plate, and is inclined to the Tarim plate. By collecting the data from previous studies, some profiles have been performed systematically to reveal the characteristics of mineralogy, petrology and lithogeochemistry of Aqishan pluton. While very fewer work on high precision isotopic age have been done, and the study on Sr, Nd, Pb isotopes have not been carried out. Methods: We use the methods of high precision isotopic age dating which called LAICPMS Zircon UPb age dating to determine the formation age of Aqishan pluton; On the other hand, we use Sr—Nd—Pb isotope geochemical tracer technique to synthetical analyse the genesis of Aqishan pluton.Results:The result of LAICPMS zircon UPb dating shows that the age of Aqishan Pluton is 269.5±1.6 Ma~272.1±1.3 Ma, indicating that the Aqishan pluton formed in Late Permian. As for the Sr—Nd—Pb isotope compositions, the rocks have low initial ratio of strontium isotope\[n(87Sr)/n(86Sr)\]i (0.70442 ~ 0.70553), positive εNd（t）values (0.48 ~ 3.66) and relatively juvenile t2CDM(741 ~ 1090 Ma) . The Sr—Nd isotope compositions suggest that their primitive magma was most possibly derived from juvenile crust with variable involvement of depleted mantle derived magma, while in the Pb tectonic framework diagram, the material source is also related to the crust—mantle interaction. In combination with the characteristics of lithogeochemistry, previous research results and tectonic background, we analyzed that Aqishan pluton is the product of crust—mantle interaction under the background of mantle plume activity. Aqishan pluton is located in the northern Xinjiang, belongs to the part of the Central Asian orogenic belt, in Late Permian, the entire northern Xinjiang has entered to postorogenic satge, and the late Paleozoic plate subduction dynamics system has ended, while the formation of postorogenic magma requires new dynamics and heat source. The underplating of mantle magmas not only provide heat source for postorogenic magmatic activity, also supply a large number of material. Therefore, under the tectonic background of regional stretch, due to intensely crust—mantle interaction, the heat source, which resulted from the underplating of deep mantle plume magmas, induced partial melting of younger crust, accompanied with the contamination of a portion of the mantle material, all of this reasulted in the Aqishan pluton possesses the doubly characteristics of mantle and crust. Conclusions:The age of Aqishan pluton is 269.5±1.6 Ma~272.1±1.3 Ma, which formed in Late Permian. The isotopic characteristics of Sr—Nd—Pb and the previous research results show that Aqishan pluton is the product of crust—mantle interaction under the background of mantle plume activity.