Objectives: The Pana Formation volcanic rocks of the Linzizong Group are widely distributed in Zhaxue area, eastern Gangdese belt, which is an important object to understand the geological evolution of the Gangdese belt. Methods: In this study, we report the results of wholerock geochemistry, zircon UPb age and Lu—Hf isotopic composition date for the Pana Formation volcanic rocks in the Zhaxue area to constrain their emplacement ages, petrogenesis and tectonic significance. Results: The LAICPMS zircon UPb age reveals that the Pana Formation volcanic rocks were erupted at 52 Ma，which is similar to the geochronology of the Pana Formation volcanic successions in the eastern Gangdese arc, indicating that there has a relatively consistent time of the Pana Formation in the Gangdese arc. Geochemical data display that these volcanic rocks have high content of SiO2content, high sodium and alkali with A/CNK values ranging from 1.30 to 1.73, suggesting that it belongs to the peraluminous shoshonite series. Meanwhile, they present obvious enrichment in LILEs (such as Rb, Th, U and K) and LREE, depletion in HFSEs (such as Nb, P and Ti), showing the arc magma affinity. These samples have low Mg#(19.77~38.96), Cr(3.00~34.3 μg/g), Ni(2.90~15.6 μg/g), Co(2.20~9.58 μg/g), and the La/Sm ratios show no significant change with the increasing content of La, suggesting that the Pana Formation volcanic rocks in this study experienced crystal fractionation in the petrogenesis. Additionally, in combination with their negative εHf(t) values (-4.4 to -3.6), the Pana Formation volcanic rocks in Zhaxue area mainly derived from partial melting of juvenile crust with some continental crust material involvement. Conclusions: Combined with the published isotopic data around the Linzhou region, the Linzizong group volcanic rocks changed from a depleted mantle in island arc environment to a relatively enriched source formed by involvement of continental crust material in collision environment over time, indicating that the formation environment underwent a transition from island arc to continental collision. What’s more, the Pana Formation volcanic rocks were considered as a magma response caused by the transfer from subduction to collision at initial stage of the Indian—Asia continental collision.