The tectonic Mapping of global Mesozoic and Cenozoic is the basis of the global tectonic theory research, which is compiled to reflect the integrated geology, geomorphology, geophysics. This paper introduced the compiling methods, data, map content, and tectonic division. We analyzed the connection relationship between global horizontal tectonic and vertical tectonic based on layer structure of earth. The midocean ridge and the subduction zone around Pacific are connected and transformed by the Indian Ocean, the Arctic ocean, Tethys tectonic zone and Antarctic plate. Antarctic plate is surrounded by the midocean ridge and absorb all of discrete motion of the global midocean ridge in the southern part of earth. In addition, the theory of tectonic equator supports the relationship between tectonic units under different global tectonic zone, which is the result of global tectonic of Mesozoic and Cenozoic adjustment. Finally, this paper discussed the global tectonic evolution of the Mesozoic and Cenozoic in the perspective of Pangea breaking.