The study of sulfate thermochemical reduction reaction (TSR) was introduced into the mineralization process, inspired by the theory of paleo- gas percolation and sedimentary mineralization of the manganese ore in eastern Guizhou, based on the study of the geochemical mechanism of the mineralization of mercury depsides in Guizhou. It is further demonstrated that the source of mercury can be either the trap system of deep reservoirs or the surrounding rocks (such as Qingxudong Formation, which varies with specific deposits). The ore- forming fluid is transported by the ore- transporting fluid which is riched in mercury (including gaseous mercury), sulfur reduction and Cl-, and also interacts with mercury in the surrounding rocks as the form of cinnabar and elemental mercury. The thermal chemical reduction of oil and gas (hydrocarbons) and sulfate at higher temperatures is the source of reducing sulfur (H2S, HS-, S2-). Oil and gas (hydrocarbons) play an important role as reducing agent in mineralization. Due to leakage or spillage of the mineral bearing hot fluid (reservoir), the fluid also dissolves the mercury in the form of cinnabar and elemental mercury at flow through the surrounding rocks, by migration of mercury into soluble mercury—sulfur complexes. Mineralization occurred at geological conditions in the system from closed to open (structure), and gas composition nonvolatile, in m(S2-) reduce elevated, Eh, pH, lower, lower pressure and temperature and salinity decrease such as physical and chemical conditions. The results show that the metallogenic mechanism of gold, antimony and other metal deposits in Guizhou is similar to that of mercury deposit. Therefore, the sedimentation—alteration origin of this kind of (mercury, gold and antimony) metal deposits since 1980s, especially the geochemical mechanism proposed by the author should be improved.