The Central Tianshan Mountains tectonic magmatic belt widely distributed with the Paleozoic granitoids, which is an important part of the Central Asian Orogenic Belt (CAOB) in Xinjiang. The LAICPMS zircon UPb dating was carried out on granitoids from Bayinbuluke and Baluntai area in south of central Tianshan Mountains, and the age were 463 ± 3Ma (quartz diorite), 437 ± 5Ma (quartz diorite), 424 ± 3Ma (monzogranite), 383 ± 4Ma (monzogranite), 356 ± 3Ma (monzogranite) and 303 ± 5 Ma (syenogranite), respectively. Through synthetically analyzed, the Paleozoic intrusive magmatism in the central Tianshan Mountain can be divided into four stages of tectonic magmatic evolution. The first stage is from late Cambrian to late Ordovician. The Terskey ocean basin and southern Tianshan ocean basin opened to form vast ocean basins in the Neoproterozoic. The Terskey ocean basin began to subduct in the late Cambrian and closed in the late Ordovician, and the southern Tianshan ocean basin northward subduction began in the early Ordovician from west to east gradually. The second stage is from early Silurian to middle Devonian. The southern Tianshan ocean basin continued to subduction northward, and the northern Tianshan ocean basin began to subduction southward and formed arc magma in the northern edge of the Yili block. The third stage is from late Devonian to early Carboniferous. The southern Tianshan basin closed at the end of the Late Devonian and started the residual oceanic basin in the middle and late of early Carboniferous. The last stage is from late Carboniferous to early Permian with postcollisional orogenic environment and continental evolution in region.