The structural analysis method of geological body combination that we propose is based on the morphological classification of geological bodies, which is an entirely new kind of structural analysis method. According to structural deformations and diverse mineralization alterations caused by the imbalance of structure of geological bodies, it follows the basic principles of deformation analysis. We analyze the typical deformation (rupture) styles of various geological bodies as well. In addition, this paper summarizes the deformation rule of stratified geological objects. In the field of mineral exploration, we present a rupture-oriented method for mineral exploration from epigenetic deposit. On this basis, we can briefly determine the target area of mineralization potential, prospecting direction to guide the ore body, judging prospecting indications and so on. In each stage of mineral exploration, the novel method has the characteristics of strong practicality and operability, and it is easy to grasp and it has a short period of study and etc. Meanwhile, our method makes a contribution to structural geology and mineral deposits, which has a great theoretical significance.