Chu—Careisu basin is located in the southeastern part of Kazakhstan, a central Asian nation, and it is one of most uraniumrich basins in the world. This article focused on its regional strata and tectonic background, analyzed the metallogenic condition and spatial and temporal distribution features, summarized on the geological—hydrogeological characteristics, including grade, thickness, depth, shape, mineral contents, chemical contents, permeability and water yield property of aquifer, discussed the reasons for its largescale, standardized and low-cost in-situ leaching mining activity based on the mining technology massively-deployed in this region, summarized several advanced ideas and practical experiences of uranium exploration and mining process of sandstonehosted uranium deposits in Kazakhstan, and proposed several suggestions for research and development of uranium resources in China's basin terrains.