Objectives: At present, the understanding of the structural and deformation characteristics of Mesozoic and Paleozoic in North Jiangsu—South Yellow Sea region is relative weak due to the data restriction of seismic, drill and outcrop, which limits the exploration of oil and gas. It is significant to establish and compare the detailed regional tectonic frameworks, and then to explore their uniformity and difference. Methods: This study investigates the uniformity and difference of tectonic deformation and evolution of Meso—Paleozoic in the North Jiangsu—South Yellow Sea region, on account of the comparison and analysis of recent regional seismic profiles. Results: Meso—Paleozoic tectonic frameworks are divided into four units. The basement and its overlying sedimentary strata experienced a process of detachment, slippage, napping and thrusting under strong squeezing. Two strike—slip systems are respectively dominated by NW with less of NNW and NNE, showing a high—angle shear relationship with near EW regional structure. Conclusions: The hedge tectonics are various. The uniformity appears as the comparability of strata, the similarity of basement and cap reflection, and the same characteristics of hedge belts and thrust folds with NW—SE inner—plate progressive deformation. The difference manifests as strong slippage to alternately of napping anticline and syncline, which is dominated acted in the body and the surface of the metamorphic rocks, followed by Doushantuo Formation on the land at the north of the hedge belt, and then it is characterized by imbrication thrust consisting of obduction (A zone), thrust (B zone) and overthrust (C zone) in the front of anticlines. The sea area is characterized by tectonic formation of deeper deep and shallow metamorphic rock ruptures, detachment and arch thrust, which are formed into two groups of high—angle thrust folds in the wide and gentle anticline. Furthermore, although North Jiangsu—South Yellow Sea area has experienced the hedge—nappe—slip stage from late Indosinian to early and middle Yanshanian, extension stage in the late Yanshanian, and rift—depression stage since late lateCretaceous, its “horn” pattern is basically unchanged, which is mainly caused by the different ways of the tectonic formations on the land and in the sea.