A series of late Mesozoic plutons are exposed in the Bengbu Uplift in the southeastern North China Craton, and record abundant deformation processes. This and previous zircon dating results show two phases of magmatism in this region, including Middle—Late Jurassic one (167~148 Ma) and Early Cretaceous one (130~112 Ma). The Late Jurassic Mayishan pluton records a NNE striking sinistral ductile deformation belt formed under the NNW—SSE compression. This strike slip deformation belt was overprinted by brittle sinistral faults during its faulting induced uplifting. Time of the strike slip deformation can be constrained between 148 Ma and 130 Ma. The region experienced intense WNW—ESE extension during 130~112 Ma, which was accompanied with magmatism and regional uplifting. The Middle—Late Jurassic Jinshan—Tushan pluton and Early Cretaceous Huaiguang pluton record a deformation process from extensional ductile detachment deformation at deep levels to shallow overprinting by brittle normal faults during the extensional activity. Other plutons in this region all show brittle normal faulting at shallow levels. The deformation in the plutons suggests that transition from compression to extension regimes in the eastern North China Craton took place between 148 Ma and 130 Ma, and provides an example for structural evolution in a non basin area during the Early Cretaceous peak destruction of the craton.