The Karamaili were located in south position of the eastern Junggar metallogenic belt of the Central Asia—Great Hinggan metallogenetic megaprovince,which were characterized by accretion—collision processes, intense tectonic—magma activity, and abundant mineral resources in the Late Paleozoic. The metallogenic processes in the Late Paleozoic had two major stages with the Devonian—Early Carboniferous in the northern Karamaili—Yemaquan and the Middle—Late period of the Early Carboniferous—Permian in the Karamaili. Based on studying of the tectonic evolution of northeastern Xinjiang, and geodynamics and mineralization characteristics of deposits, This paper suggested that the polymetallogenic systems in the Late Paleozoic in the Karamaili were divided into different types of (1) the porphyry-type gold metallogenic systems in the Devonian active continental margin, (2) the epithermal—porphyry-type copper—gold metallogenic systems formed extrusion-stretching conversion stage in the Middle—Late period of the Early Carboniferous arc—continental collision, (3) the orogenic-type gold—copper metallogenic systems and⑷the magmatic—hydrothermal tin—gold metallogenic systems in the Late Carboniferous—Permian post collisional extension stage after arc—continental collision.The latter three types of the polymetallogenic systems in the Karamaili were the main factors responsible for the formation of deposits. The major genetic types of polymetallic deposits were composed of the ductile shear zone-type gold deposits,the epithermal-type gold deposits, the magmatic—hydrothermal vein-type gold deposits，the porphyry-type copper—gold deposits, the tectonic-controlled vein-type copper deposits and the greisen—quartz vein-type tin deposits. The authors hold that (1) the porphyry-type gold metallogenic systems in the Devonian active continental margin in the northern Karamaili—Yemaquan could have been superimposed by the Late Carboniferous—Permian post-collisional gold metallogenic systems to fail to recognize; (2) it were dominant for the polymetallogenic systems in Karamaili to post-collisional environment, and (3) metallization were conducted by effect on strke-slipping and extensional tectonics, crust—mantle magmatic mixture interaction and mixed fluid mineralizing process derived from lithospheric delamination and underplating asthenosphere mantle as geodynamic mechanism.