Based on the detrital apatite fission track analysis on the modern sediment from flood plain in the Wujiang River, we plotted out 3 peak values: P1〖CD2〗5.9Ma; P2〖CD2〗27.6Ma; P3〖CD2〗82.3Ma, all the peaks resulted from the periodical tectonic events occurred in the Wujiang River catchments. The consistency between a series of important tectonic events and experimental results reveals that the fission track ages recorded important tectonic events in the eastern Yunnan—Guizhou Plateau since Mesozoic—Cenozoic. The main control factors of P3, P2 and P1 are uplift movements in the Late Cretaceous, slowly uplifting as well as faulting in the late Oligocene and regional quickly uplift events in the Miocene—Pliocene respectively. Among the results, the large scale regional tectonic uplift events as indicated by P1 associated with climate change accelerated significantly erosion process, which implies that deep gorgecutting by the Wujiang River most likely formed after 5.9Ma.