In order to scientific appraise the potential of important mineral resources in China，firstly，this paper objectively analyses the current situation of mineral resources prediction；moreover，three geochemical quantitative forecasting methods are reviewed and commented，whose names are abundance method，areal productivity method，and geochemical block method. Secondly，through summarizing and absorbing previous achievements，and integrating four disciplines composed by fundamental geology，mechanism of diagenesis and metallogenesis，theoretic geochemistry and exploration geochemistry，we generalized the establishment of geological—geochemical prospecting model，targeting method of geochemical potential prospecting area and mineral resources calculation on GIS platform. Finally，with reference to geochemical quantitative prediction， some conclusions are summarized and further development orientations are explored.