Mesozoic granitoids are widespread in southern Hunan, central Nanling district, and there are a lot of tungsten, tin, molybdenum, lead—zinc deposits in this area, which constitute a worldclass nonferrous metallic deposit cluster, among them, many tungsten and tin deposits are large and giantscaled. The known geochronological data reveal that, the metal mineralization including tungsten, tin, lead—zinc deposits was an explosive regional event, and predominately took place during 150 to 160 Ma, largely coincides with the timing of granitoid intrusion in this area. For an individual mining district, granitoid emplacement and related hydrothermal mineralization are basically penecontemporaneous, i.e., tungsten—tin mineralization occurred contemporaneously or immediately after granite intrusion. Therefore, the tungsten—tin mineralization are temporally, spatially and genetically associated with granitoids in central Nanling district. The largescale granitoid intrusion and explosive tungsten—tin mineralization formed under the geodynamic setting of lithospheric thinning and crustal extension, probably are closely connected with the second episode lithospheric extension event during the Mesozoic.