Though there have been controversies concerning relationships among weathering rate and tectonic andclimatic change，it is commonly recognized that chemical weathering of silicate minerals plays a substantial rolein regulating the partial pressure of atmospheric carbon dioxide and thus in maintaining global surface climaticstability over the geological timescale． How to understand the constraints on chem ical weathering of silicateminerals remains a major challenge，especially when any single climatic factors have been proved hard tointerpret the long—term silicate weathering rate．Based on the compilation of chem ical weathering rates of silicateminerals and physical erosion rates in different settings，this study shows that weathering rates and tectonic andclimatic changes on different spatial and temporal scales have coupling or even conflicting relationships．Suchresults suggest that the silicate weathering rates cannot be explained in terms of merely a single process，andthat the explanation requires a consideration of mu ltiple factors． Although influence of tectonic uplift issuggested to serve as an important role on the change of silicate weathering，it may be cursory to link variouschanges on the Earth’S surface in the Late Cenozoic to the stepwise uplift of the main orogenic belts，especiallyof the Himalayan- Tibetan orogen．In different settings，tectonic and climatic constraints on silicate weatheringare not necessarily incompatible，especially on time scales of a few m illion years．Thus，the hypothesis proposedfor“tectonic uplift -chem ical weathering- climatic changes”is faced with a new challenge．