Geological factors affecting petroleum chromatography compounds fingerprint are analyzed based on the process of the commingled production well and the heterogeneity of reservoir rocks and fluid distribution. The change of petroleum chromatography compounds is studied by modelling underground temperature and time interval in laboratory. Simulation results show that petroleum chromatography compounds fingerprint will be steady in underground and subsurface temperature. At the same time, they will be similar in different production period. The result will cough up a new thought in the quantitative simulation of reservoir performance.