This paper, through analyses of the geological settings and ore-forming conditions of the uranium deposits in South China, points out that the metallogenetic epoch of uranium ranges from 90-50 Ma, and that the ore-forming is closely related to Late Mesozoic red basins, granite bodies and reduced-material-bearing layers. It is correlated with the Proterozoic unconformity-related uranium deposit in Australia. Then a generalization of the metallogenetic model of Mesozoic unconformity-related uranium deposits is made, and the prospecting criteria and orientation are suggested.