Uranium deposits and oil accumulation occur in the same depression in the Erlian Basin. This phenomenon is not occasional. It shows a certain relation of uranium and oil in origin. This paper introduces and analyses the evidence for the relation between uranium deposits and oil accumulation in terms of space distribution, geology, hydrochemistry and geochemistry. This study reveals the relation of uranium and oil in formation and distribution and explains the formation reason of uranium deposit, connected with oil accumulation. It is important to use uranium as an indicator to prospect for oil and vice versa to find uranium.