Abstract: The fractal dimensions of folds are related to layer thickness and viscosity of the multilayer. This paper discusses how the thickness, viscosity, and anisotropic degree affect the rheological deformation of fractal folds in multilayers. The number of layers, their thicknesses, viscosities, and anisotropic degree of multilayers cooperate to affect the rheological deformation of folds, which is not controlled by a single rheological factor. A greater anisotropic degree of multilayers is favorable to develop the more complex and disharmonious fractal folds.