The Baiyun sag, located in the Zhu 2 depression of the central Pearl River Mouth basin, has undergone a complex evolution from a Mesozoic active continental margin to a Cenozoic passive continental margin. Recent expansion of oil and gas exploration targets to deeper buried hills necessitates a comprehensive understanding of the structure and genesis of these uplifts. This study employs 3D seismic and borehole data to analyze the structural characteristics of uplifts around the Baiyun sag and investigate their formation processes. Our findings reveal distinct genesis for these uplifts, categorized into three types: the Panyu low uplift, mainly controlled by Mesozoic thrust faults; the Yunkai low uplift, jointly controlled by Meso- Cenozoic faulting; and the Yundong low uplift, mainly governed by Cenozoic extensional faults. This diversity in uplift structures is related to the degree and type of interaction between Meso- Cenozoic faults. Mesozoic pre- existing faults determined the complexity of the basement structure, while subsequent Cenozoic faulting, both inheriting and modifying these pre- existing faults, resulted in the observed variety of uplift structures. Late- stage magmatism and fault modification further enriched this diversity. Furthermore, we investigated reservoir formation conditions in buried hills, identifying weathering, faulting, and magmatism- related fractures as the main reservoir spaces that exhibit regular planar distributions. Therefore, by studying the differences in uplift genesis, we can not only investigate the interactions between pre- existing and late extensional faults but also provide a structural basis for understanding reservoir formation and evaluating exploration targets in buried hills.