Lop Nor, containing abundant potassiumrich brine, is one of the most important saltforming basin in China. Past 14 years of industrial mining show changing geochemical characteristics of brines in different ore layers. In order to estimate the spatial geochemical distribution of potassiumrich brines in different mining areas and utilize brine water resources, we have used the Kriging interpolation method to analyse the spatial distribution of 89 brine samples collected in 2017, and drawn the contour maps of K+, Cl-, Na+, Mg2+, Li+, B3+, SO42-. The results show that K+, Cl-, Mg2+, Li+, B3+ have a relatively consistent distribution trend. The high value area is mainly located in the Luobei depression and the northern part of the Tenglong platform, and the low value areas are located in the north of the Luobei depression and southwest of the mining area. However, the SO42- distribution trend is reversed. Due to the influence of freshwater 〖JP〗supply from the surrounding areas, desalination occurs in the southwest, north and southeast of the mining area; however, only W1 and W2 layers were affected, and the W3 layer shows no obvious desalination. The average K+ content of Lop Nor is 8. 83g/L. Except for the area affected by fresh water, the KCl grade in most areas was higher than the industrial separate mining grade of 1%. Compared with KCl grade before mining, the average grade of KCl in W1 layer of Luobei depression is about 9. 7%.