The Middle-Lower Yangtze River Valley is one of the most important Cu-Fe polymetallic belts in China, in which occurs many volcanic basins, such as Li-Shu, Li-Yang, Ning-Wu, Fan-Chang, Lu-Zong, Huai-Ning and Jin-Niu volcanic basin. Compared with the uplift area in this region, the researches on the petrogenetic and metallogenetic in the volcanic basin are still poorly investigated. Basing on the summaries of the contributions of the previous researchers as well as our fundamental studies in recent years mainly on Lu-Zong basin and Ning-Wu basin, this paper discussed the geological characteristics, the temporal-spatial framework, geochemistry, geochronology of petrogenesis and mineralizations and metallogenetic model of the volcanic basins in the Middle-Lower Yangtze River metallogenetic belt. The chronological results of the igneous rocks suggests that the magmatic rocks in the volcanic basins formed in early Cretaceous (135~123Ma). The geochemical features of the volcanic rocks and the intrusive rocks in the volcanic basins indicate that their evolution, sources and the origin of the four formation volcanic rocks and the two epochs of intrusions are comparable. The source of the igneous rocks might be the metasomatic mantle, the formation of the metasomatic mantle was related to the subduction of the paleo-Pacific plate. The magma evolution underwent fractional crystallization and in the magma chamber and contamination during rising. Iron is the main mineralization occurred in the volcanic basins, which represented by the “porphyry iron deposits”. The “porphyry iron deposits” include a series of volcanic-subvolcanic hydrothermal deposits, sedimentary-reformed deposits, pyrite deposits, anhydrite deposits and alunite deposits. The geological and geochemiscal characteristics of these deposits indicated that their formation were closely related to the subvolcanic rocks (diorite porphyry) and diorite intrusions, and also controlled by the volcanic structures and the basal halites in the Triassic strata. The mineralization chronology shows all the porphyry iron deposits are “booming” formed around 130Ma in a short interval. This paper proposes a petrogenetic and metallogenetic model for the volcanic basins in the Middle and Lower Reaches of the Yangtze River area metallogenetic belt. The petrogenetic and metallogenetic in these volcanic basins is one part of Mesozoic tectono-magmatic-metallogenic event controlled by the geodynamic setting of eastern China in the Yanshanian period.