The problems of the Qinghai-Tibet plateau uplift have never failed to attract researchers' attention. The formation of permafrost in the Qinghai-Tibet plateau resulted from temperature decreasing due to rising elevation. Rising rate is believed to be closely related to formation history and current configuration of permafrost and it is very likely that the permafrost contains the Qinghai-Tibet plateau uplift information. Our study presumed a scenario in which it would take 2 Ma and 5 Ma years to lift for one place to rise from 1000 m to 5000 m. The calculation shows that different rising rate may result in the different thickness of permafrost. In the model with a low rising rate, permafrost has much time for heat conduction, thus permafrost tends to be much thick and old. Based on the thickness of existing permafrost, geotherm change, and age and precise parameters of permafrost, this study acquired some understanding about uplift’s time and process of the Qinghai-Tibet Plateau.