When investigating on the formation of hydrothermal metal deposits, observation and experiment are always closely integrated. In the 70’s of last century, the rapid accumulation of the experimental data of the mineral water equilibrium thermodynamics had been used to predict and retrieve the origin and geneses of ore and rock by using the calculation of the thermodynamic theory. However, no mineral aqueous solution reaction rate data, and without the combination of fluid mechanics, and to understand clearly the origin and geneses of the ore deposition is difficult. 7080s, scientists began to study the reaction kinetics of minerals in aqueous solution. They began to aim at the new direction from the equilibriumclosedstatic system to nonequilibriumOpenkinetics study. In 1992 we set up the laboratory of geochemical kinetics. Experimental study obtained the reaction rate of mineral(or rock) in water at high temperatures and high pressures, and also found the selforganization in the open system. Experiments indicated that the temperature affected the dissolution rates of minerals, found that the fluctuation rates of minerals in water when crossing the critical state. Results also indicated that some metals can be transported in vapor phase during metal fluids fallen into vapor liquid twophase immiscibility regions in subcritical region. The oxidation of supercritical fluid and special solvent effects on mining dissolution were also investigated. The experimental results show that the fluid across the critical state is related to the ore genesis. The reaction kinetics of water rock interaction experiment at temperature from low temperature to 550℃, reveal the metal source, migration, metal and alteration zoning mechanism. A large number of mineral dissolution rates data at temperature above 300℃ were rarely reported in the international community. Recent years, the scientific development of ultrahigh pressure study, combined with the technical progress of synchrotron radiation light source, leads the solid earth science to enter the earth’s deep interior. We developed a high temperature and high pressure in situ observation methods, and direct measurement 850℃ aqueous solutions, and obtained infrared spectrum, the new properties of deep fluid, new structure of the vaporliquid twophase fluid, in the critical temperature (300 to 400℃). The destruction of hydrogen bond networks of water molecules is derived from decreasing density and dielectric constant across the critical state of water. At the same time, the water exhibits high conductivity. Invention of new experimental instruments for the open flow nonequilibrium reaction experiments and the combination of In Situ observation of fluids properties under extreme conditions lead to create new scientific field of science frontier.