The Southwest Sanjiang metallogenic belt, one of the most important nonferrous metals and precious metals metallogenic belt in China, possesses large amount of Zn- Pb- Cu- Ag- Sb- Au resources. This study presents the metallgoenic features and resources potential from perspectives of main metallogenic characteristics and geological conditions, mineral species and deposit type. The southwestern Sanjiang metallogenic belt located in the eastern Tethys Himalayan tectonic domain is the collisional zone between Eurasian plate and Indian plate collision. It is characterized with complicated tectonic structure, well developed strata and frequent magmatic activities, indicating it is of preferential ore forming conditions. The belt contains 20 and more metallogenic systems: Au- Cu- Mo- Zn- Pb metallogenic series related to alkaline rich porphyry; Pb- Zn metallogenic series associated with carbonatic rock to clastics; and Au- Ni- Cr metallogenic series associated with ductile shear zone of collisional orogeny, etc. The main mineral species are Zn, Pb, Cu, Ag, Au and Sb, and main deposit types are porphyry, sedimentary reformation and MVT. This paper selected the Lanping Jinding super large zinc lead ore deposit and Heqing Beiya super large gold ore deposit as examples to introduce their geological features. It is confirmed that the super large deposits are characterized by superimposed mineralization. According to the latest results of national mineral resources potential assessment, this study summarized the predicted mineral resources for 20 and more minerals including Zn, Pb, Cu and other minerals, and defined 24 key prospecting areas, including copper and polymetallic areas of Duocai area of Qinghai, Cu Mo metallogenic area of Xiariduo duoxiasongduo area in Tibet, Zn Pb Cu metallogenic area of the Lanping Yunlong area in Yunnan, and Au and other metals metallogenic area of the Heqing Xiangyun area in Yunnan. Main mineral species and deposit types in 13 key prospect areas were outlined for next prospecting task.