Hainan- Western Guangxi Southeast Guangxi metallogenic belt comprises Southeast Guangxi, Southwest Guangzhou and Hainan island. This area is the conjuncture zone of Euraasia, India and Pacific plates. Based on new research result and exploration progress, a new metallogenic belt was generated and named after Hainan West Guangxi and Southeast Guangdong metallogenic belt. This belt is with favorable ore- forming environment and various minerals.The characteristics of typical deposits were summarized and 14 mineralisation series were generated with ore deposit spectrum. The mineralization potential in this belt was also being assessed. The main deposit types are sedimentary metamorphic type, hydrothermal sedimentary type, hydrothermal vein type, contact metasomatic type, porphyry type and supergene type. Mineralization process was controlled by structures. Based on the research, Au- Ag- Fe- key prospective zone of Yunfu in Guangdong, Au- Ag- prospective zone of Luchuan area in Guangxi and Fe Au prospective zone in Hainan were generated, which could support mineral exploration in this belt.