The Wuyishan Cu- Pb- Zn polymetallic metallogenic belt is an important belt located in the Cathaysia block. This area had long experienced convergence of global supercontinents and breakup of north and south continents, and was endowed with preferential mineralization background and conditions, suggesting that it should be a key prospecting area. Starting from the history of tectonic evolution, the study analyzed metallogenic geological settings and then established its metallogenic lineage. Based on the assessment result of national mineral resources potential, prospecting progress and new theory, a suggestion for next prospecting in this area was proposed, withmineral species including REE, fluorite, Cu, Mo, Pb, Zn, Sn, Au and Ag as target elements. The major deposits in the area contain weathering leaching REE deposit, porphyry type Cu- Mo deposit, sedimentary deformation Zn Pb Ag polymetallic deposit, magmatic hydrothermal fluorite deposit and felic rock related hydrothermal W- Sn- Bi- Mo- Nb- Ta deposit. 19 target prospecting areas in this belt were defined including eight for key prospecting areas and 11 for average areas.