On the basis of compilation of assessment for mineral resources, new geological theory and our prospecting results, this study re defined the boundary of the Tianshan Beishan Cu- Ni- Au- Pb- Zn metallogenic belt, which is located between Siberian plate and Tarim plate. It has gone through multi stages tectonic activities, including several breakup, convergence and orogeny, resulting in the formation of many large and super large deposits with a variety of mineral species and types. Therefore, this belt should be the preferential areas for prospecting breakthrough. With the focus on the tectonic evolution and the latest prospecting progress, authors analyzed the regional geological background and summarized the metallogenic lineage of the Tianshan Beishan Cu- Ni- Au- Pb- Zn metallogenic belt. This has deepened our understanding of the metallogenic belt. A new round of assessment for resources potential confirms that it is of big resources potential. 19 prospective areas were defined, including nine key prospecting areas and 10 average areas. This study proposes the possibility to find new deposit type (such as sandstone type uranium ore deposits and porphyry type gold deposits) and new mineral species (rare metals). The area was found to enrich in elements such as Ni, Cu, Mo, Au and W, as well as Pb, Zn, Fe and Mn.It is suggested that the next prospecting should concentrate on mafic ultramafic Ni Cu deposits, porphyry type Cu (Mo Au) deposits, crushed alterated rock Au deposits, carbontic rock clastic rock Zn Pb Au deposits, marine volcanic iron deposits and skarn type gold deposits and sedimentary Mn deposits, and so on. This study will be of some guiding significance to next prospecting work plan in the Tianshan Beishan Cu- N-i Au- Pb- Zn metallogenic belt.