South China is the most important tungsten and tin metallogenic region in China. Centering on the large- scale granite- related tungsten and tin mineralization in South China, this paper preliminarily summarizes their main types and temporal- spatial distribution characteristics based on a systemic review of the updated information of deposit geology and isotopic chronological data of more than 130 major deposits. The results show that the skarn and quartz- vein types are the most important tungsten mineralization styles in South China, while skarn type and cassiterite- sulfide are the most important tin mineralization styles. Granite- related tungsten and tin mineralization in South China show multiple- aged characteristic, but the major mineralization of both tungsten and tin is formed in the Yanshanian period. The tungsten mineralization represented by the Nanling and Ganbei metallogenic belts mainly occurred from the Late Jurassic to the early stage of Early Cretaceous (160~120 Ma), while the most important tin mineralization in South China is composed of the Late Cretaceous (110~80 Ma, peak period 90~80 Ma) tin deposits in the Youjiang basin and the Late Jurassic (160~150 Ma) tin deposits in the Nanling metallogenic belt. An important feature of granite- related tungsten and tin deposits in South China is that a variety of different mineralization styles or metal assemblages occur in the same deposit or ore field, and an understanding of these features is of great significance for guiding ore exploration. In this regard, by taking Yaogangxian, Maoping- Taoxikeng, Shizhuyuan, Dachang and Gejiu as examples, this paper proposes several metallogenic models and prospecting directions for granite- related tungsten and tin mineralization in South China based on recent exploration progresses and metallogenic studies. In addition, on the basis of petrological and mineralogical characteristics of tungsten and tin granites, this paper summarizes the chemical characteristics of fluid and melt of granitic magmatic hydrothermal system and accordingly explores the fluid and melt inclusion chemical index for evaluating the tungsten and tin mineralization potential of granite. This may expand the exploration index for granite- related tungsten and tin deposits.