Cobalt ore deposit is one of the significant strategic metal minerals. The in- depth study of its mineralization (such as the relationship between structure and mineralization) can provide the theoretical basis for guiding ore prospecting. Based on the research of Dahenglu Cu- Co mine in Sanchahe Village, Sandaogou Town, Baishan City, Jilin Province, China, the field structural deciphering, drilling and core data analysis, TIMA test of drilled sections and regional rock chronology are mainly carried out. Structural deciphering shows that the country rock of Dahenglu Cu- Co mine includes bedding- cleavage interaction, S1 cleavage, and crenulation cleavage. A large number of F2 closed folds, thrust faults, and their related asymmetric folds, and overturned folds are developed in the Dahenglu Cu- Co mine based on drilling holes and cores analysis. TESCAN Integrated Mineral Analyzer (TIMA) experiments of thin section samples from boreholes and exploratory trenches show that Co- containing fluids are enriched in the low- angle thrust faults, the ductile shear domain of overturned folds, and the hinge zone of fault- related folds. These works show that the NE low- angle thrust fault and fault- related fold play a key role in controlling the enrichment of the Dahenglu Cu- Co deposit. Combined with previous studies, a large number of regional geological data, and the relevant geochronological data show that: ① the ore- controlling structures such as thrust fault and fold in the mine area are the products of the Paleoproterozoic tectonic event. ② The restriction of Mesozoic tectonic events on mineralization (Cu- Co ore re- enrichment) may come from the large- scale extension produced by the Cretaceous tectonic event.