The metallogenic system theory regards ore deposit as a natural system of dynamic evolution. The overall evolution process of ore deposit from occurrence, formation, to development and its control mechanism are the core of this theory. “Source, migration, storage, transformation, and protection” are the five basic points for this theory to analyze the genesis of ore deposit.The superhuge potash deposit in the Khorat Plateau in Southeast Asia is a landmark successful case of Chinas overseas potash fertilizer production base.The systematic study of metallogenic mechanism is not only related to understanding of the genetic process of the deposit and its development and utilization, but also plays an important guiding role in the prospecting of potash in the eastern Tethys domain of China.Based on the previous researches and the metallogenic system theory, the study will sort out the research status of “source, migration, storage, transformation, and preservation” metallogenic factors of the Khorat Plateau potash deposit, and discuss its scientific problems in the time dimension. Moreover, the study will preliminarily propose the research framework of the metallogenic system of solid soluble potash deposit, in order to provide a certain reference for the indepth research on global potash deposits.