The Zhuxi deposit is a tungsten-copper deposit dominated by skarn ore bodies, it yielded near the contact zone between the Yanshanian intermediate-acid intrusive rocks and the Late Paleozoic carbonate formation in the Jiangnan tungsten belt. Skarn and vein-type copper ore bodies are developed in the shallow, and skarn-type tungsten-copper ore bodies,greisen-vein-type tungsten ore bodies and altered- granite-type tungsten ore bodies are developed in the deep.The garnet sample from shallow skarn-type copper ore body yielded the U-Pb age of 152.6±2.6 Ma, the U-Pb ages of the sheelite sample from the greisen-vein-type tungsten ore body and the skarn-type tungsten-copper orebody in the deep are 153.4±2.2 Ma, 153.9±2.7 Ma, respectively. The three ages are consistent within the error range, indicating that the tungsten and copper mineralization formed in the same hydrothermal system, and the Zhuxi porphyry-skarn deposit developed the spatial zoning of “upper copper and lower tungsten”.Combined with the trace element characteristics of two types of scheelite from greisen-vein-type tungsten ore body and skarn-type tungsten-copper ore body, the fluid originated from a highly differentiation magmatic hydrothermal solution rich in WO42- and low Sr. The substitution mechanism of REE3 + for Ca2 + in the Zhuxi scheelite was probably Ca site vacancy, and the distribution behavior of rare earth elements recorded the properties of different types of ore-forming fluids. The greisen-vein-type tungsten mineralization formed in the reducing environment, the obvious decreasing of oxygen fugacity and the large amount of Ca2 + provided by surrounding rock promoted the precipitation of scheelite. The skarn-type tungsten copper mineralization is a relatively open hydrothermal system, which experienced an increase in oxygen fugacity in the later stage, which enhanced the fluid’s ability to accumulate Cu metal, thereby extracting and activating the copper element in the surrounding rock into the fluid. The lowering of the temperature causes the metasomatism of carbonate minerals and anhydrous skarn minerals, leading to the precipitation of copper. The skarn-type tungsten-copper deposit is transformed into a relatively open hydrothermal system. The increasing oxygen fugacity in the later stage enhanced the metal copper carring ability, so that the copper extracted from surrounding rock entered the ore-forming fluid, followed by a decrease in temperature caused and anhydrous skarn minerals to be altered to hydrous skarn minerals leading to a deposit size of the copper former.