For a long time, the margin of the sedimentary basins played a vital role in sandstone type uranium deposit prospecting and exploration. In recent years, however, several uranium deposits and mineralization spots have been discovered in the interior of the basins, presenting a good exploration potential of uranium deposit. This paper studied the characteristics of uranium deposits in the interior of the basins and summarized the crucial uranium ore- controlling metallogenic elements of “large igneous upwelling area and fractures in the edge of upwelling area”. Combined with the metallogenic theory of sandstone- type uranium deposit, a set of combination of suitable prospecting methods is designed, which can be divided into two steps. Firstly, preliminary screening of exploration target area. According to regional gravity, magnetic, radioactive and remote sensing data, the relief and burial depth of the basin basement, lithology classification, and faults division was identified. The upwelling area with intermediate- acid igneous rock and developing faults was delineated as potential exploration target area. Subsequently, the exploration target was preliminarily screened with a combination of features of the ore- bearing strata, the slope and area of upwelling area. Secondly, exploration target area was optimized. In the preliminary screened exploration area, several drill holes were arranged and drilled in the area from deep and large faults to the upwelling area. By comprehensively evaluating the groundwater “recharge, runoff and drainage” system, the uranium supply, accumulation capacity and development of redox transitional zone of ore- bearing strata, favorable exploration target area could be selected, which provides useful guidance for the layout and implementation of uranium exploration work in the next step. This method makes full use of regional geophysical data and open downloadable data, which can greatly reduce the exploration cost. Focusing on the key elements of uranium- controlling mineralization and selecting appropriate geological and geophysical methods can effectively improve the efficiency of prospecting and exploration of sandstone type uranium deposits in the interior of the basin.