The Nadanhada region in northeast China is located in the easternmost part of the Central Asian orogenic belt. Its Late Mesozoic- Cenozoic tectono- thermal evolution history is key to understand the orogenic activity of the continental margin. However, previous studies in this area are limited, and the Mesozoic- Cenozoic thermal evolution history lacks effective constraints. Hence we take Nadanhada region as the main research area in this study and apply multiple low temperature thermochronological methods including apatite fission track, zircon, and apatite (U- Th)/He to study the tectonic thermal evolution history of the Nadanhada region. The thermochronological datas and thermal history modeling results reveal that there are two rapid cooling events in the late early Cretaceous to late Cretaceous (110~80 Ma) and Paleocene to Eocene (60~40 Ma), with cooling rates of 3.42~4.81 ℃/Ma and 1.43~1.83 ℃/Ma, respectively. Combined with the history of regional tectonic setting and the geological data, it is concluded that the two cooling processes are controlled by Pacific subduction. The late Cretaceous rapid cooling was caused by a change in the subduction direction of the Pacific plate, and the collision between the Okhotsk block and the East Asian continental margin. The Eocene rapid cooling was mainly caused by the roll- back of the subducting Pacific slab, which placed the East Asian continental margin in an extensional environment, resulting in the exhumation and the following cooling events at most areas in Northeast China. This study enhances understanding of the Mesozoic- Cenozoic tectono- thermal evolution history of the East Asian continental margin, and it is of great significance to understand the process and mechanism of tectonic deformation in intracontinental orogenic belt.