The tectonically active southeastern coast of China is located in the subduction zone of the Eurasian Plate and the Philippine Sea Plate. At the same time, this area is also the main source of high radioactive granite in China. Development of large areas of Mesozoic acid granite bodies has resulted in abundant occurrence of hot dry rock. On the basis of regional geothermal and geological background, the Xiamen bay- Zhangzhou basin in the southeast coast of Fujian was selected for detailed investigations. The formation conditions of hot dry rock resources in this area are systematically analyzed from the perspective of regional geothermal flow, geothermal gradient, geothermal temperature, hot water circulation depth and deep temperature of geothermal reservoir. A suitable depth for exploration of the future hot dry rock resources in this area is scientifically calculated based on the data. The results show that (i) the average geothermal gradient in the area is about 18. 3℃/km, lower than the average value for the continental areas; and (ii) the radioactive heat generation rate of the granite is only slightly higher than the global average value of the granite. The relatively high value of surface heat flow in the area is mainly due to mantle heat conduction, and the contribution of radioactive elements to heat generation is relatively low. The future development of hot dry rock resources in the area should take full account of the influence of deep heat source conditions, the thickness of ground cover and regional faults on drilling engineering. These factors will provide a framework guiding future exploration and development of hot dry rock resources in this area.