The accidental discharge of pollutants and the remediation of contaminated sites after the relocation of industrial and mining enterprises face various problems, which pose a serious threat to the use of groundwater resources. Groundwater VOCs pollution has the characteristics of easy diffusion and migration, high toxicity, high risk, and high restoration difficulty. Based on typical deep groundwater remediation cases, this paper fully analyzes the field geological background and hydrogeological conditions, discusses the remediation mechanism, objects and technical characteristics of various remediation technologies according to the pollutant characteristics, contamination range and distribution characteristics of pollutants, and conducts performance comparison and applicability analysis for VOCs remediation. At the same time, through the comprehensive research of two stages of tests, the combination of in situ and ectopic technology, it provides a basis and idea for carrying out the practice and management of VOCs pollution remediation of similar groundwater.