The orogenic gold deposit is globally an economically important mineralization and is thus the main objective of themineral exploration inthe Bangong- Nujiang Copper Polymetallic Resources Base. The Bangong- Nujiang metallogenic belt is one of the most important porphyry- epithermal- skarn copper and gold resource belt that has been recognized and developed in the recent decade in China. The Shangxu gold deposit, situated in the middle of the Bangong- Nujiang belt, is the first orogenic gold deposit in this metallogenic belt. Mineralization is hosted by the Early to Middle Jurassic turbidite of the Mugagangri Group, and comprised of quartz lodes, carbonate+quartz veins and altered rocks, with lentoid, massive, laminated, saddle, disseminated, brecciated structures. Mineralization is controlled by the NWW- stretching regional fault system. Hydrothermal alteration includes carbonatization, muscovitization, chloritization and sulfidation. The mineralogy and the characteristics of gold lodes indicate that the early hydrothermal activity developed in a compressional environment,and the compression stressdecreased and disappeared in the late hydrothermal stage. This could correspond to a late tectonic deformation setting. The Rb- Sr isotopes of quartz fluid inclusions lead to an isochron age of 135. 6±2. 7 Ma, with an average initial 87Sr/86 Sr value of 0. 713, indicating that mineralization developed in the Early Cretaceous, and the ore- forming materials were sourced from the crust. Integrated study shows that the formation of the Shangxu gold deposit was coincident with the closure of the middle Bangong- Nujiang suture during the Early Cretaceous. The compression stress between terranes caused regional deformation and metamorphism of the host rock of the Mugagangri Group. During thechanging tectonic setting in the late compression deformation, stress relief might have led to gold mineralization. A comparison study shows that the Shangxu gold mineralization shares similarities in deposit geology, hydrothermal alterations, ore- forming fluids, tectonic settings andgeodynamic settings with large and world- class orogenic gold deposits around the world, indicating the potential of orogenic gold mineralization along the Bangong- Nujiang belt.