By the end of 2018, proven resource reserves in the Hubei Province included 91 minerals and 1418 mines. Based on the latest radiometric dates, this paper discusses the tectonic- stratigraphic- magmatic spatiotemporal evolution of the six tectonic stages including the Lvliang, the Jinning, the Caledonian, the Indosinian, the Yanshanian, and the Himalayan. Various processes including magmatic mineralization, sedimentary metallogenesis, metamorphic metallogenesis, surface metallogenesis, as well as fluid metallogenesis involved in their evolution are discussed. Furthermore, 6 groups of minerogenetic series of deposits and 32 minerogenetic (sub- ) series were identified, and their metallogenic regularity summarized. Three explosive mineralization periods have been determined in Hubei. Phosphorous deposits were mineralized by biochemical processes in the Baokang- Shengnongjia- Yichang- Zhongxiang area during the Early Sinian. From late Jurassic to early Cretaceous, large- scale Fe- Cu- Au polymetallic metallogenesis related to magmatic metallogenesis occurred in the southeastern Hubei. Gypsum- salt- petroleum were deposited in the Jianghan basin during the Cretaceous- Paleogene.