Nanling metallogenic belt is an important uranium resource base of China. The granite type is the dominant uranium deposit type,with carbonaceous silicous- pelitic rock type and some sandstone type uranium deposits occurring as minor types. In this study, we compile and analyze the available literature on uranium prospecting, exploration and scientific research. We confirm that the favorable geological conditions for mineralization of uranium i.e. the initial source of uranium, uranium productive granitic massif, nets of fault junctures, uranium hydrothermal etc.were formed during the multi- stage tectonic evolution of Nanling metallogenic belt. Most of the uranium productive granitic massifs are the S- type granites characterized by high content of Si, peraluminous, meta- potassium and alkali. The favorable ore- bearing wallrocks are the cataclastic rocks, altered rocks and reductive geological bodies which are distributed along the faults. The mineral assemblage formed in the central zone of mineralization and alteration is composed of pitchblende, black microcrystalline chalcedony, purple black fluorite, colloidal pyrite, hematite, chlorite etc. Uranium ore bodies are mainly medium to small in scale, and of medium to low industrial grade. The research onmetallogenic regularity indicates that the multi- stage uranium mineralization occurred during the regional extension in the Meso- Cenozoic. Granite- type uranium deposits are distributed near the contact zones or in the internal tectonic junction of granite rock bodies from the Caledonian uplift area. The orebodies along the fracture and in the erosional geological bodies are distributed in the “metallogenic crust” between the oxidation- reduction interface and the transition plane of brittle and ductile structure. The “holomorphic space” uranium mineralization model shows that there could be potential mineralization places in different tectonic layers, formations, lithology and spaces. However, the types, scales, and metallogenic times of uranium deposits are different due to the diversity of metallogenic conditions in different sites implying thatno space can be excluded as a potential site for mineralization. Under this assumption, new uranium prospecting breakthroughscan be made based on the specific ore- forming conditions in the working areas. Summarising, the uranium mineralization in the Nanling metallogenic belt in Mesozoic- Cenozoic is comprehensively analyzed from different perspectivein this study based on the recognition of “holomorphic space mineralization”.