Isotope geochronology is a newly developed science which determines the geological body formation and geological event occurrence times according to the radioactive isotope decay law, and is also the main means of studying the metallogenic age. Combined with the work of our and previous study, this paper introduces several isotopic geological dating methods that can directly determine the mineralization age of rare metals and its applications, so as to provide references for related disciplines. The main methods are: ①Re- Os method, which is the most mature method to directly determine the metallogenic age of metal deposits at present. Besides molybdenite, the measurement objects have been expanded to pyrite and pitchblende, etc. ②U- Pb method, which is the most widely used method in geological research, is now not limited to zircon. U- pb age of some uranium- bearing ore minerals, such as cassiterite, monazite, apatite and niobium- tantalum, can also be directly determined, which is helpful to determine the metallogenic age of metal deposits. ③Ar- Ar method, with wide rang of measurement objects, in princeple, all the K- bing mierals and rocks can be used for Ar- Ar isotopic dating; ④Rb- Sr method, which is widely used, has made great progress in the study of metallogenic age in recent years. It can be used to determine the metallogenic age using the Rb- Sr isochron of inclusions, or can be dated by using different mineral associations of the same origin.