The late Neoproterozoic witnessed at least two glacial events on a global scale, namely, the Sturtian and Marinoan. In the Zouma area of West Hubei, the Nanhua System Gucheng Formation and Nantuo Formation belong to the Sturtian and Marinoan glacial deposits respectively. The Datangpo Formation represents the interglacial deposits and is also an important Manganese- forming period. This study conducted geochemcial analysis for fine clastic rock samples of the Guchegn, Dtangbo and Nantuo formations from the ZK702 drill core in the study area, and calculated the characteristic valuses of the CIA, CIW, PIA, Al/Ca, Rb/Sr, V/Cr and U/Th, to understand the paleoclimate and paleo- oxygen facies evolution from glacial to interglacial in the Nanhua period. Petrological evidence also suggests that the climate of Gucheng glacial period was cold and dry (CIA value changed from 69. 2 at the bottom to 57. 8, at the mean value of 62. 2), and the paleotemperature of early interglacial period in the Datangpo increased and tended to stable (CIA ranging from 54. 3 to 62. 7, with a mean of 59. 7), and the climate of late Datangpo returned to warm humid and tended to be stable (CIA value ranging from 70. 2 to 81. 1, with a mean of 75. 8). The climate of the Nantuo glacial period became cold and dry again (the CIA value decreased from 78. 6 to 61. 9). The paleoclimate evolution reflected by CIW, PIA and Rb/Sr values is consistent with that of CIA values. The change of Al/Ca values also reflects that the fluctuation of terrigenous clastic was input with paleoclimate. The V/Cr, U/Th and Ni/Co ratios show that the study area during Gucheng Period to early Nantuo Period was generally in an oxidation environment. Among them, the paleo- ocean during the early stage of Datangpo period was in sub- oxidation environment, while the other periods were in the oxidation environment. The manganese in Datangpo deposited in a sub- oxidation environment in the early interglacial cold climate, and the manganese stopped deposition after the climate became warmer. The mineralization of manganese deposits was coupled with paleoclimate and paleo- oxygen facies.