The Wulungu depression, located in the northeastern margin of Junggar basin, is of great potential for hydrocarbon accumulation. However, less exploration has been performed in this area and a low- cost, high- efficiency and wide- area oil reconnaissance survey is needed urgently to outline target areas of optimized oil and gas reservoir. In this study, airborne hyperspectral, geological verification and oil and gas chemical exploration are used to evaluate the hydrocarbon exploration potential and related altered minerals data. The results show that oil and gas micro- seepage anomalous are characterized by circular zonation. Field survey also suggests that the part of anomalous areas has some geological features (such as circular zonation on surface, clayization, carbonatization and vegetation poisoning etc), which all are related oil- gas seepage. Seepage hydrocarbon was accumulated near the surface in four forms, stratiform, stripe, massive spots and adsorption. Oil and gas migrated along faults and fractures in the form of hydrocarbon molecule, which is so- called chimney effect. The hydrocarbon micro- seepage in the study area is controlled by unconformity structure, secondary thrust fault and corrugation structure. According to regional tectonic evolution and hydrocarbon accumulation history, authors suggest that a large- sized oil and gas seepage may start from the Yanshanian, and reach to a peak in Himalayan period. It can be concluded in this study that the uplift in the middle of study area is of good potential for gas- oil accumulation and will be the key area for future oil- gas exploration.