Niutangjie large tungsten deposit locates in the south of the Miaoershan- Yuchengling batholith in Northern Guangxi. The ore bodies are closely associated with a slightly chloritized fine- to medium- grained granite. The whole- rock geochemical characteristics of this granite indicate that it is a peraluminous, highly fractionated and evolved, W- rich granite. Zircon in situ U- Pb dating of this granite yielded a diagenetic age of 410±4.9 Ma. The in situ U- Pb dating of apatite co- existed with scheelite in ores gave a metallogenic age of 418±37 Ma. The two ages indicate that both diagenesis and mineralization of the Niutangjie tungsten deposit occurred in the Caledonian period. This paper also carried out a systematic study on the ores of Niutangjie tungsten deposit. Firstly, according to the alteration types, three different types of ores were divided: skarntype ore, chloritized ore and quartz vein (lump)- type ore. Secondly, by the characteristics of these ores, three metallogenic stages were divided: skarnization stage, quartzsulfide stage and the late silication- carbonation stage. These three metallogenic stages are corresponding to the three different types of ores. Thirdly, thein situ trace element compositions of scheelite in each metallogenic stage were analyzed. According to the Mo contents and Eu anomalies in REE patterns of scheelite, the variation trend of the oxygen fugacity was constrained. By the changes of Na and Nb contents and the REE patterns of scheelite, the mechanisms of REE substituted into scheelite and the evolution of metallogenic fluid were revealed. Fourthly, the oxygen isotopic datum of scheelite reveal that the metallogenic fluid is magmatic water mixed with meteoric water. Fifthly, the W compositions of the parental granites indicate that the metallogenic materials of the Niutangjie tungsten deposit originates from the ore- forming parental rock. Thus, the Caledonian highly fractionated and evolved granites in this tungsten deposit are important sources of metallogenic materials.