Hightemperature, highpressure and high- salinity brine in the Jiangling depression of Jianghan basin is rich in K, Li, B, I, Rb and Cs elements, contents of which have reached the industrial grade or exceeded the comprehensive utilization grade. But this K- and Li- rich brine deposit has long faced difficulty in locating its position. The relationship between enrichment of K- and Li- rich brine and structure of ore field has not been identified. With the guide of modern ore field geology, the paper analyzed the ore field structure of brine and ore field mineralization based on geophysics, wells and fields data. Affected by tectonic locations, each area of the Jjiangling depression shows very different local structures developed in different periods. The orderly distribution and superimposition of these local structures forms abundant structural traps, which provide favorable places for the enrichment of LiK brine. During the deposition period from Shashi Formation of Paleocene to Xingouzui Formation of Early Eocene, the high temperature and dry paleoclimate of Jianghan basin was favorable for the evaporation of salt lake, and K- and Li- bearing materials from volcanic activities provided base for the enrichment of Li- K brine. Structurereservoir coupling accumuation mode of K- rich brine in the Jiangling depression and deposition characteristic of salt lake have determined that a large amount of brine accumulates in the strata. The biggest reservoir space for brine is sandstone pores. Tectonic movement resulted in the formation of a large amount of fractures in mudstone and igneous rock, which become the ideal places for brine accumulation. Due to structural fold and burial diagenesis, brine migrated from salt crystal to sandstone pores, finally into fractures and volcanic system.