To understand the genesis of uranium mineralization within the Middle-Lower Jurassic sandstone and its relationship with hydrocarbon fluids in the northwestern margin of Junggar basin, this study carried out an analysis of carbon isotope and Re-Os isotope. Carbon isotope and Re-Os testing of the oilsand extract indicate that the hydrocarbon initially originated from source rock of the Lower Permian Fengcheng Formation (P1f), and was firstly charged in 155±51 Ma owing to the destruction of the deep hydrocarbon reservoir during late Jurassic to early Cretaceous period. Field geological survey, core macroscopic and microscopic identification suggest that the sandstone were subjected to twostage epigenetic oxidization before and after hydrocarbon injection. The intensive early oxidation resulted in great potential for hematite mineralization. While weak later oxidation gave rise to the widespread ferritization and possible a smallscale metallogenic process. At last, a fourstage uranium metallogenic model was established for reduction and epigenetic oxidation of hydrocarbon fluids within the middlelower Jurassic sandstone. The primary reductive orebearing formation formed in the earlymiddle Jurassic. ②The paleo interlayer oxidation type uranium deposits formed during the middlelate Jurassic. ③The hydrocarbon filling and the upper mudstone cover from Cretaceous to Neogene. ④The modern interlayer oxidation zone and uranium mineralization formed since Quaternary. The proposed model is of significance for sandstonetype uranium deposits prospecting in petroliferous basins.