The Hongshigangbei mafic intrusion was discovered by No.704 Geological Party，Xinjiang Geological Exploration Bureau for Nonferrous Metals in 2014. It is located in East Tianshan, and controlled by the KangguerHuangshan ductile shear zone. The mafic intrusion is composed predominantly of diorite, hornblende gabbro and olivine gabbro, with a minor amount of sufide droplets in gabbro occasionally. Sulfide mineral assemblages are composed of pyrrhotite, pentlandite and chalcopyrite. In order to accurately evaluate the prospecting potential of the intrusion, we investigated the zircon UPb chronology, mineral chemistry, geochemical and SrNd isotopic characters of the intrusion. Combining with the geophysical characteristics, we compared the Hongshigangbei intrusion with the typical NiCu sulfide deposit in East Tianshan area. The zircon UPb isotope age of 276.1±5.4 Ma reveals that the mafic intrusion was formed in Early Permian. Olivine crystals in the Hongshigangbei rocks have a narrow range (Fo=69.9~72.6) and the Ni content of 101×10-6~1326×10-6. The clinopyrexene and orthopyroxene belong to endiopsidediopside and enstatite respectively. The values of MgO (5.95%~13.06%) and FeOT show positive correlation, but there is negative relation between MgO and SiO2, CaO and Al2O3. All the samples are slightly enriched in LREE and positive Eu anomaly. Trace elements show a LILErich and HFSEdepleted(Nb,Ta) pattern. The (87Sr/86Sr)i and εNd(t) rations range from 0.70342~0.70349 and +7.51~+8.25(t=276Ma) respectively, indicating that the source of intrusion was depleted mantle. The SrNd isotope trend reveals that the parental magma of the Hongshigangbei intrusion experienced about 5% crustal contamination during upwelling. Compared with the typical NiCu sulfide deposits in East Tianshan, the Fo contents and major elements contents of the Hongshigangbei intrusion are in a low and narrow range. But they are similar in isotope age, trace elements, SrNd isotopic characteristics, degree of crustal contamination and material. This indicates that the characteristics of magma sources, tectonic setting, composition of parental magma and evolution process may have obvious similarity between Hongshigangbei intrusion and Huangshandong, Huangshan deposit. On the basis of the study above, we speculate that the deep of intrusion may exist ultramfic rocks.Geophysical data also indicate that the Hongshigangbei intrusion has lower polarization rate than the typical NiCu sulfide deposit in East Tianshan. But they have similarity in surface magnetic anomaly, residual gravity anomaly and resistivity. These characters show that the deep of the Hongshigangbei intrusion may exist orebearing ultramafic intrusion. In conclusion, we believe that the deep of Hongshigangbei intrusion has large NiCu prospecting potential.