To study the sedimentary source and sedimentary tectonic setting of the lower Permian Maérzheng Formation in the southern margin of East Kunlun, detailed strata division, sedimentary environment and detrital zircon UPb geochronology were taken for the Lower Permian Maérzheng Formation in Gerizhuotuo area in the southern margin of East Kunlun in this paper. The results show that the Maérzheng Formation is a set of turbidite formed in bathyalsea continental slope. Detrital zircon UPb age spectrum can be explicitly divided into Early Paleozoic and Neoproterozoic two main age spectrum and the Paleoproterozoic Mesoproterozoic secondary age spectrum. The main age spectra were 396~573 Ma and 727~947 Ma, the peak age was 421 Ma and 862 Ma, respectively. The secondary age spectra were 1117~1993 Ma and 2319~3063 Ma, the peak age was not obvious. Combined with geological data in the study area and its adjacent area, it is considered that the sedimentary source of Maérzheng Formation in Gerizhuotuo area in the south margin of the East Kunlun is complex which shows characteristics of source supplied from multiple times, as Early Paleozoic, Neoproterozoic, Mesoproterozoic and Proterozoic. Early Paleozoic magmatic rocks and Neoproterozoic magmatic rocks in East Kunlun orogenic belt provide about 60~65 percent of sediment source and old metamorphic basement provides only about 30~35 percent of sedimentary debris for Maérzheng formation. Combined with previous data, we suggest that Maerzheng Formation formed in extensional system related to the passive continental margin tectonic setting, and the oceanic crust subducted from late Permian.