The Nanhua “Ancient Natural Gas Seep Sedimentary Manganese Ore Deposit” is located in the subrifting basin of Wuling in the conjunction area of Guizhou, Hunan and Chongqing. It formed in the extension background of Rodinia super continent and has become the most important Mn ore deposit in China.  Through summarizing the geological setting of the ore deposit, and paleogeographical and geological features of structure and ore deposit in Early Nanhua period, we established the exploration models of this ore deposit based on the metallogenic model of “Ancient Natural Gas Seep Sedimentary Manganese Ore Deposit”. Models include: (1) Geological exploration model based on characteristics of the Early Nanhua Period synsedimentary faults and secondary graben basins, the existence of ancient natural gashosted dolomite lens of the Liangjiehe Group, geological bodies of manganese ore deposit, the thickness of Datangpo Group strata, and central, transitional and marginal facies of seep eruption. (2) Geochemical exploration model based on distinguishable Mn/Cr ratio in samples from IV and III rift basins and distinguishable sulfur isotopic signatures in different facies (central facies, transitional facies and marginal facies). (3) AMT (Audiofrequency Magnetotellurics) geophysical exploration model based on physical property differences between Mnbearing rocks (low electrical resistivity, high polarizability) and its overlying and underlying strata (high electrical resistivity and low polarizability). Through application of this exploration models, our research group has successively discovered two superlarge concealed manganese ore deposits in Daotuo and Xixipu of Songtao, Guizhou Province, which are also two superlarge concealed manganese ore deposits in Asia. Recently, another two superlarge massive manganese ore deposits were discovered in Guizhou Province, which has made eastern Guizhou Province a new worldclass manganese ore resourceabundant region. The Ancient Natural Gas Seep Sedimentary Manganese Ore Deposit has become one of the most significant three manganese deposits in the world, after traditional marine deposits and sedimentary metamorphism deposits.