Chinese Central Tianshan Block, located in the central part of the Tianshan Orogenic Belt, is of significant importance for understanding the tectonic evolution, origination and continental growth of the Central Asian Orogenic Belt. This paper focuses on petrogenesis and tectonic implications of Paleozoic granitoid intrusions from the Baluntai region in the western part of the Central Tianshan Block. We report zircon LA ICP MS U Pb geochronological and MC ICP MS Lu Hf isotopic results for seven granitoid intrusion from the study area, and their whole rock major and trace element characteristics. The seven intrusions presently studied were respectively emplaced at 435±5 Ma, 432±4 Ma, 359±4 Ma, 312±4 Ma, 346±2 Ma, 306±5 Ma and 362±5 Ma. The petrographic and geochemical features suggest that those Paleozoic granitoid intrusions are typical I type granite in genesis, and were mainly derived from the partial melting of different types of deep crustal sources. Besides, mantle derived magmas played an important role in genesis of some intrusions. Based on present and previous data, three episodic magmatic events are identified in the Baluntai region, i.e., Early Silurian to Early Devonian event (435 to 408 Ma) magmatic event, Late Devonian to Early Carboniferous (370 to 339 Ma) magmatic event and Late Carboniferous to Middle Permian (313 to 263 Ma) magmatic event. The first stage magmatism was not only associated with the final closure of the Paleo Tianshan Ocean, but also a result of the subduction of the South Tianshan Ocean (STO). The magmatic quiescence during Middle to Late Devonican was likely related to the suspension of subduction of the STO. The second stage magmatism was likely related to the northward subduction of the STO, and the third stage magmatism plausibly occurred in post collisional settings after the final closure of the STO. According to the regional scale Hf isotopic mapping of Paleozoic granitoids in the Baluntai region, we suggest that the Precambrian basement rocks were predominately formed at three stages, i.e., (1) ~2.47 to ~2.26 Ga continental growth, responding to the global continental crust growth, (2) ~1.47 to ~1.25 Ga continental growth, associated with the breakup of the Columbia supercontinent and (2) ~1.14 to ~1.02 Ga, overlapping with so called “Grenville ages” of 1300 900 Ma that are thought to be resulted from the assembly of the Rodinia supercontinent.