The Seripu gold deposit is located in the middle Gangdise metallogenic belt and, belongs to the scope of Dabu copper molybdenum deposit. Our study shows there are three types of fluid inclusion related to mineralization in: gaseous, liquid, and halite, by means of microphysiography, microscopic temperature measurement and Laser Raman microprobe analysis on quartz fluid inclusion of ore bearing quartz vein. The variation range of the homogenization temperature is about 117℃～377 ℃,with average salinity of the fluid inclusion nearly 2.57%～45.59% NaCleqv.The fluid inclusion is mainly medium-high heat and high salinity. Besides CO2, there is CH4 and N2 also in the gaseous. It was the estimated ore-forming pressure is close to 120～130 MPa, with lithostatic pressure depth nearly 4 km～4.3 km. The depth of the hydrostatic pressure is nearly 12 km～13km, and fluid density approaches 0.68 g/cm3. By combining with the H-O isotopes analysis results, this paper insists that the main source of metallogenic fluid is from magma, with small part of meteoric waters involved in the late stage.Daughter minerals containning and polyphase inclusion coexist with different filling percentage liquid or gaseous phase, with closely homogenization temperrature and different salinity, reflecting that metallogenic fluid experiences boilling.