The reef-bank carbonatite of Upper Ordovician Lianglitage Formation in the eastern Tazhong area is the principal zone producing oil and gas. In order to find out the features of stratigraphic framework and the control mechanism of its inner sedimentary microtopography to the reef-bank complex reservoir, we established the high frequency sequence stratum framework of Upper Ordovician Lianglitage Formation in this paper, based on the analysis of lithology, depositional microfacies, welwitschiopsida and logging curves. The framework can be divided into 11 four-stage sequences and multiple five-stage sequences. The second and third passages of Lianglitage Formation mainly deposited in highstand systems tract, which is characterized by continuous vertical accretion and is the main developmental phase of reef (mound) and bank combination rimmed deposits. One or more sedimentary microtopography cycles of reef-bank complex can be developed in a four-stage sequence. The thickness and scale of reefal microtopography are controlled by secondary eustatic sea level change cycles and tectonic subsidence. According to the analysis of diagenetic fabric and diagenetic environment, we believe that the atmospheric diagenetic lens formed during syngenetic karst is mainly distributed in the top of upward shallowing cycle and highland of microtopography. Exposition controlled by reefal microtopography uplift in the same sequence and sea level change in the relative movements, with dissolution and eluviation of syngenetic atmospheric fresh water are the key factors for not only the favorable reservoir development of reef-bank complex in the platform edge, but also the difference between sequences and zones. Features of high frequency sequence framework and its control mechanism to the reef-bank complex reservoir are present in this paper, which have been used to direct the exploration and exploitation of reef reservoir of Ordovician in the eastern Taizhong area and have achieved some success.